No, they will not. I checked with Titan an their Chain Cable Tire Chain item # TC751DC you were looking at do not fit the 2023 Ford F-150 Lightning with 275/50R22 tires. Additionally, your owner's manual says not to use tire chains because of clearance issues on the inner part of the tires. Which means the ones we do have for your Lightning's 275/50R22 like item # KON64FR won't work. With this in mind, I only have one set that will work and it is not an inexpensive option.
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